Female Infertility Therapy: Current Practice

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Book Info

(Martin Dunitz) Univ. and Hadassah, Jerusalem, Israel. Papers from a Serono Symposium held at the Royal College of Physicians in London on September 16-17, 1998. Details the clinical questions and problems arising from the variety of treatments now available in this field. For practitioners and researchers. Halftone illustrations. Well-referenced.

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Annotation 

The book contains black-and-white illustrations.

From the Publisher

Shoham, Zeev, MD(Kaplan Medical Centre); Howles, Colin M., PhD, FRSM(Ares-Serono International SA, Geneva); Jacobs, Howard S., MD, FRCP, FRCOG (Univ Coll London)

Table of Contents

List of contributors 

Preface 

Pt. I Drug Regulation and Effects 

1 In utero exposure to gonadotrophins   3

2 Risk and the use of drugs in infertility treatment   11 

Pt. II Reproductive Dysfunction 

3 Genetically determined reproductive dysfunction in women   27 

Pt. III Polycystic Ovaries 4 Molecular genetics of the polycystic ovary syndrome   35 

5 Polycystic ovary syndrome: mode of treatment   45 

6 Novel approaches to the management of the polycystic ovary syndrome with GnRH agonists   69 

7 Optimizing protocols for ovulation induction 75 

8 Detrimental effects of LH hypersecretion   85 

Pt. IV Recombinant Drugs 

9 Basic knowledge about recombinant gonadotropic hormone production   95 

10 The use of recombinant human FSH in in vitro fertilization   103 

11 The use of recombinant human FSH in ovulation induction   115 

12 The use of recombinant luteinizing hormone, gonadotrophin-releasing hormone agonist or human chorionic gonadotrophin to trigger ovulation   125 

13 Ovarian stimulation with highly purified FSH and ovulation induction for IUI   137 

Pt. V GnRH Agonists and Antagonists 

14 GnRH and its agonistic analogues: basic knowledge   157 

15 GnRH agonists: to dose or to overdose?   167 

16 The role of meta-analysis in determining which gonadotropin to use for ovarian stimulation   177 

17 GnRH agonist protocols: which one to use?   189 

18 The use of GnRH antagonists in IVF   203 

Pt. VI In Vitro Fertilization and Micromanipulation 

19 Different treatment protocols for different indications   215 

20 The use of lasers for micromanipulation   221

21 Cryopreservation of oocytes   233 

22 Should ICSI apply to all IVF cycles?   243 

23 In vitro maturation of human oocytes   253 

24 Elimination of high-order multiple gestations by blastocyst culture and transfer   267 

25 Cryopreservation of ovarian tissue   275 

26 Improving embryo culture and enhancing pregnancy rate   283 

Pt. VII Side Effects of Treatment 

27 Ovarian hyperstimulation and the polycystic ovary syndrome   303 

28 The use of intravenous albumin for prevention of severe ovarian hyperstimulation syndrome   309 

29 How to avoid multiple pregnancy   317 

30 What are the cancer risks?   325 

31 Benign ovarian teratomas (dermoid cysts): changing trends in management and impact on fertility   337 

Pt. VIII Endometriosis 

32 Endometriosis: pathophysiological and diagnostic considerations   347 

33 Endometriosis and infertility: pathogenesis and work-up   355 

34 Genetic factors in endometriosis   363 

35 Principles of management of endometriosis: surgical treatment   373 

Pt. IX Implantation 

36 The implantation process: lessons from ART   393 

37 Clinical assessment of uterine receptivity   407 

Index   419